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Consumption of a excessive-fats weight loss program has been linked to increased intestine permeability, which allows more LPS to enter the circulation and seems to contribute to the development of both insulin resistance and obesity.99 This altered gut permeability includes modifications in the distribution of the tight junction proteins zonula occludens-1 (ZO-1) and occludin, as well as adjustments in the endocannabinoid system.a hundred Muccioli and colleagues discovered that intestine microbes selectively modulate colonic expression of the

 

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