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as some of their U.S. colleagues. Smoking was immediately and justifiably rejected as a viable protective measure for COVID-19 due to its well-established adverse health effects . However, a protective role for nicotine was suggested based on the fact that cytokine storm is a hallmark of severe COVID-19 while the cholinergic anti-inflammatory pathway, mediated mainly through nAChRs, can suppress the hyper-inflammatory response and promote immune homeostasis . Nicotine is a cholinergic agonist that has been found to inhibit the release of pro-inflammatory cytokines,

 

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