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air pollution on DNAm has also been investigated in adults. It should be noted, however, that in many of these studies, early life exposures were not recorded and may influence the results seen in adult volunteers. In one study from our group, exposure to freshly generated diesel exhaust (standardized to 300 μg/m3 of PM2.5) for 2 h modulated DNAm at 2827 CpG sites in blood samples collected 30 h later, relative to filtered air exposure . DE exposure induced a decrease in DNAm on

 

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