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reporting. Anaphylactic reactions have occurred in up to 1 in 10,000 vaccine recipients. Systemic allergic reactions characterised by generalized urticaria and accompanied in some circumstances by arthralgia, angioedema, fever, nausea and vomiting have been reported. These reactions are uncommon in individuals receiving primary immunization however have occurred in as much as 7% of those receiving a booster dose, with onset 1 to 21 days after immunisation. Such reactions have been shown to comply with the event of IgE antibodies to beta propiolactone-altered human serum albumin in the vaccine. Neurologic problems are

 

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