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modulated by allergen, DE, or co-exposure in bronchial brushings at 48 h. However, when the same lung tissue was exposed to an allergen and then to the allergen and DE a month later, 548 CpG sites were modulated . These results suggest that exposure to an allergen may prime the lungs for responsiveness, which results in more significant effects on subsequent co-exposure to air pollution and an allergen. However, the mechanisms underlying such effects at the level of DNAm are unclear.

 

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