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ANT2, and ANT4 are able to protect cells from death. In addition, several regulators interact closely with the PTP core proteins, in particular Hexokinase II, the translocator protein , and Creatine Kinase which interact with VDAC in cytosol, outer membrane, and intermembrane space , respectively . PTP opening can also be modulated via chemical modifications of PTP partners or through interaction with several pro- or antiapoptotic proteins. Indeed, thiols oxidation of ANT protein or proapoptotic members of the Bcl-2 family (i.e., Bax, Bak, and t-Bid) are well-known

 

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