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coatings proceed to launch antibiotics at low concentrations for longer periods of time rising the risk of antibiotic resistance. Finally, there are in vitro studies recording that some antibiotics provoke cell toxicity. Specifically, Ince et al. mentioned that the decreased osteoblastic activity may be attributed to the inhibition of protein synthesis provoked by the gentamycin at concentration higher than one hundredμg/mL . Furthermore, Antoci et al. demonstrated a discount in the osteoblast proliferation after the cells publicity to ciprofloxacin, tobramycin, and

 

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