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nicotine products have been available for years and have been administered for months, even in non-smoking patients, without significant side-effects , it is perhaps timely to propose a clinical trial of pharmaceutical nicotine in COVID-19 patients. Another aspect of the interaction between nicotine and COVID-19 relates to its effects on ACE2. While previous studies have shown that smoking and nicotine down-regulate ACE2 , recent genetic studies report that smoking up-regulates ACE2 .

 

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